| Function | Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites. Required for proper progression through S phase and subsequent mitotic entry. Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation. Participates in establishing tolerance innate immune memory through non-transcriptional feedback. Mechanistically, negatively regulates TLR-induced NF-kappa-B signaling by targeting and removing the 'Lys-63'-linked polyubiquitin chains on MYD88. Negatively regulates the activation of type I interferon signaling by mediating 'Lys-63'-linked polyubiquitin chains on RIGI and IFIH1. Deubiquitinates also ASC/PYCARD, the central adapter mediating the assembly and activation of most inflammasomes, and thereby promotes inflammasome activation. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 3Deubiquitinating Enzyme 3Ubiquitin Thioesterase 3Ubiquitin-Specific-Processing Protease 3 |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | NucleusCytoplasmLocalizes Preferentially With Monoubiquitinated H2a To ChromatinUpon Nf-Kappa-B Signaling ActivationExits The Nucleus |
| Alternative Protein Names | Ubiquitin Carboxyl-Terminal Hydrolase 3 proteinDeubiquitinating Enzyme 3 proteinUbiquitin Thioesterase 3 proteinUbiquitin-Specific-Processing Protease 3 proteinUSP3 protein |
Information sourced from Uniprot.org
