Human TSPAN12 protein (Recombinant) (N-His) (STJP010800)

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STJP010800
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TSPAN12-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TSPAN12
Gene ID: 23554
Uniprot ID: TSN12_HUMAN
Immunogen Region: Gly111-Arg224
Immunogen: Homo sapiens (Human)
Function Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
Protein Name Tetraspanin-12
Tspan-12
Tetraspan Net-2
Transmembrane 4 Superfamily Member 12
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Tetraspanin-12 protein
Tspan-12 protein
Tetraspan Net-2 protein
Transmembrane 4 Superfamily Member 12 protein
TSPAN12 protein
NET2 protein
TM4SF12 protein
UNQ774 protein
PRO1568 protein

Information sourced from Uniprot.org

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