| Post Translational Modifications | Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1. |
| Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis.the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-ST-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan. It may also play a role in the extracellular release of microvesicles that differ from the exosomes. |
| Protein Name | Tumor Susceptibility Gene 101 ProteinEscrt-I Complex Subunit Tsg101 |
| Database Links | Reactome: R-HSA-162588Reactome: R-HSA-174490Reactome: R-HSA-917729Reactome: R-HSA-9610379Reactome: R-HSA-9615710 |
| Cellular Localisation | CytoplasmEarly Endosome MembranePeripheral Membrane ProteinCytoplasmic SideLate Endosome MembraneCytoskeletonMicrotubule Organizing CenterCentrosomeMidbodyMidbody RingNucleusMainly CytoplasmicMembrane-Associated When Active And Soluble When InactiveNuclear Localization Is Cell Cycle-DependentInteraction With Cep55 Is Required For Localization To The Midbody During Cytokinesis |
| Alternative Protein Names | Tumor Susceptibility Gene 101 Protein proteinEscrt-I Complex Subunit Tsg101 proteinTSG101 protein |
Information sourced from Uniprot.org
