Tissue Specificity | Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. |
Post Translational Modifications | Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity. |
Function | Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus. |
Protein Name | Tripeptidyl-Peptidase 1Tpp-1Cell Growth-Inhibiting Gene 1 ProteinLysosomal Pepstatin-Insensitive ProteaseLpicTripeptidyl AminopeptidaseTripeptidyl-Peptidase ITpp-I |
Database Links | Reactome: R-HSA-381038 |
Cellular Localisation | LysosomeMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
Alternative ELISA Names | Tripeptidyl-Peptidase 1 ELISA kitTpp-1 ELISA kitCell Growth-Inhibiting Gene 1 Protein ELISA kitLysosomal Pepstatin-Insensitive Protease ELISA kitLpic ELISA kitTripeptidyl Aminopeptidase ELISA kitTripeptidyl-Peptidase I ELISA kitTpp-I ELISA kitTPP1 ELISA kitCLN2 ELISA kitGIG1 ELISA kitUNQ267 ELISA kitPRO304 ELISA kit |
output | |
Information sourced from Uniprot.org