| Post Translational Modifications | Phosphorylated on Ser/Thr and Tyr residues. Phosphorylated on Thr-323 in the C2-type tensin domain following EGF stimulation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex. EGF induces tyrosine phosphorylation in a time- and dose-dependent manner. Phosphorylation of the SH2 domain enhances interaction with PEAK1. |
| Function | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization. Enhances RHOA activation in the presence of DLC1. Required for growth factor-induced epithelial cell migration.growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation. Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA. Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration. Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1. |
| Protein Name | Tensin-3Tensin-Like Sh2 Domain-Containing Protein 1Tumor Endothelial Marker 6 |
| Database Links | Reactome: R-HSA-8875513 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell ProjectionPodosomeLocalizes To Both Focal And Fibrillar Adhesions But Is Mostly Found In Fibrillar Adhesions |
| Alternative Protein Names | Tensin-3 proteinTensin-Like Sh2 Domain-Containing Protein 1 proteinTumor Endothelial Marker 6 proteinTNS3 proteinTEM6 proteinTENS1 proteinTPP protein |
Information sourced from Uniprot.org
