| Post Translational Modifications | Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-518 is required for interaction with SRC and is observed during association with clathrin-coated pits. Polyubiquitinated by NEDD4 and NEDD4L. Degradation can be induced by EGF and is lysosome-dependent. |
| Function | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP. |
| Protein Name | Activated Cdc42 Kinase 1Ack-1Tyrosine Kinase Non-Receptor Protein 2 |
| Database Links | Reactome: R-HSA-9842663 |
| Cellular Localisation | Cell MembraneNucleusEndosomeCell JunctionAdherens JunctionCytoplasmic Vesicle MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleClathrin-Coated VesicleMembraneClathrin-Coated PitCytoplasmPerinuclear RegionCytosolThe Tyr-284 Phosphorylated Form Is Found Both In The Membrane And NucleusCo-Localizes With Egfr On EndosomesNuclear Translocation Is Cdc42-DependentDetected In Long Filamentous Cytosolic Structures Where It Co-Localizes With Ctps1 |
| Alternative Protein Names | Activated Cdc42 Kinase 1 proteinAck-1 proteinTyrosine Kinase Non-Receptor Protein 2 proteinTNK2 proteinACK1 protein |
Information sourced from Uniprot.org
