| Function | Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. |
| Protein Name | Tudor And Kh Domain-Containing ProteinTudor Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmMitochondrionProbable Component Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During MeiosisColocalizes With Pi- And Pip-BodiesA Subset Of The Nuage Which Contains Secondary PirnasAssociated With Mitochondria In The Germline |
| Alternative Protein Names | Tudor And Kh Domain-Containing Protein proteinTudor Domain-Containing Protein 2 proteinTDRKH proteinTDRD2 protein |
Information sourced from Uniprot.org
