| Post Translational Modifications | The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (TMEM8A), removing an acyl-chain at the sn-2 position of GPI and releasing CRIPTO as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (GPLD1) into a soluble form. |
| Function | GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. |
| Protein Name | Protein CriptoCripto - Egf-Cfc Family MemberCripto-1 Growth FactorCrgfEpidermal Growth Factor-Like Cripto Protein Cr1Teratocarcinoma-Derived Growth Factor 1 |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1433617Reactome: R-HSA-2892247 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedReleased From The Cell Membrane By Gpi Cleavage |
| Alternative Protein Names | Protein Cripto proteinCripto - Egf-Cfc Family Member proteinCripto-1 Growth Factor proteinCrgf proteinEpidermal Growth Factor-Like Cripto Protein Cr1 proteinTeratocarcinoma-Derived Growth Factor 1 proteinCRIPTO proteinCRIPTO-1 proteinTDGF1 protein |
Information sourced from Uniprot.org
