| Function | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly. TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. |
| Protein Name | Transcription Initiation Factor Tfiid Subunit 1Cell Cycle Gene 1 ProteinTbp-Associated Factor 250 KdaP250Transcription Initiation Factor Tfiid 250 Kda SubunitTaf(Ii250Tafii-250Tafii250 |
| Database Links | Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-674695Reactome: R-HSA-6804756Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-75953Reactome: R-HSA-76042 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Transcription Initiation Factor Tfiid Subunit 1 proteinCell Cycle Gene 1 Protein proteinTbp-Associated Factor 250 Kda proteinP250 proteinTranscription Initiation Factor Tfiid 250 Kda Subunit proteinTaf(Ii250 proteinTafii-250 proteinTafii250 proteinTAF1 proteinBA2R proteinCCG1 proteinCCGS proteinTAF2A protein |
Information sourced from Uniprot.org
