| Post Translational Modifications | The disulfid bond with SUN2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction. Ubiquitinated, targeting it for degradation. |
| Function | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome.SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2. |
| Protein Name | Nesprin-2Kash Domain-Containing Protein 2Kash2Nuclear Envelope Spectrin Repeat Protein 2Nucleus And Actin Connecting Element ProteinProtein NuanceSynaptic Nuclear Envelope Protein 2Syne-2 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | Nucleus Outer MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmic SideSarcoplasmic Reticulum MembraneCell MembraneSingle-Pass Membrane ProteinCytoplasmCytoskeletonMitochondrionNucleusNucleoplasmMyofibrilSarcomereZ LineDifferent Isoform Patterns Are Found In The Different Compartments Of The CellThe Isoforms Having The C-Terminal Transmembrane Span Can Be Found In Several Organellar Membranes Like The Nuclear EnvelopeThe Sarcoplasmic Reticulum Of MyoblastsOr The Lamellipodia And Focal Adhesions At The Cell MembraneThe Largest Part Of The Outer Nuclear Membrane-Associated Protein Is CytoplasmicWhile Its C-Terminal Part Is Associated With The Nuclear EnvelopeMost Probably The Outer Nuclear MembraneRemains Associated With The Nuclear Envelope During Its Breakdown In Mitotic CellsShorter Soluble Isoforms Can Be Found In The Cytoplasm And Within The NucleusIsoform 8: Cell JunctionFocal AdhesionIn U2os Cells |
| Alternative Protein Names | Nesprin-2 proteinKash Domain-Containing Protein 2 proteinKash2 proteinNuclear Envelope Spectrin Repeat Protein 2 proteinNucleus And Actin Connecting Element Protein proteinProtein Nuance proteinSynaptic Nuclear Envelope Protein 2 proteinSyne-2 proteinSYNE2 proteinKIAA1011 proteinNUA protein |
Information sourced from Uniprot.org
