Human SPAG5 protein (Recombinant) (N-His) (STJP007650)

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STJP007650
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SPAG5-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SPAG5
Gene ID: 10615
Uniprot ID: SPAG5_HUMAN
Immunogen Region: Met976-Asp1098
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by AURKA.
Function Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU.
Protein Name Sperm-Associated Antigen 5
Astrin
Deepest
Mitotic Spindle-Associated Protein P126
Map126
Cellular Localisation Cytoplasm
Cytoskeleton
Spindle
Spindle Pole
Chromosome
Centromere
Kinetochore
Midbody
Microtubule Organizing Center
Centrosome
Cytoplasmic Granule
Centriolar Satellite
Colocalizes With Pcm1 At Centriolar Satellites Throughout The Cell Cycle
In A Punctate Pattern In Interphase Cells
During Mitosis
Detected At Spindle Poles During Prophase
Throughout The Spindle In Metaphase And Anaphase
And At Midzone Microtubules In Anaphase And Telophase
Efficient Targeting To The Mitotic Spindle May Depend Upon Phosphorylation By Gsk3b
Detected On Kinetochores Of Chromosomes That Have Congressed
The Astrin (Spag5)-Kinastrin (Skap) Complex Localizes To The Microtubule Plus Ends
In Non-Mitotic Non-Stressed Cells
Shows A Microtubuli Pattern
In Arsenite-Stressed Cells
Accumulates In Stress Granules
Alternative Protein Names Sperm-Associated Antigen 5 protein
Astrin protein
Deepest protein
Mitotic Spindle-Associated Protein P126 protein
Map126 protein
SPAG5 protein

Information sourced from Uniprot.org

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