| Post Translational Modifications | Sumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting. Sumoylated. Sumoylated with SUMO1. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting. Sumoylation may stabilize the interaction with CBX5. (Microbial infection) Immediate early protein IE1 of human cytomegalovirus (HHV-5) interferes with the sumoylation of SP100. |
| Function | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. |
| Protein Name | Nuclear Autoantigen Sp-100Nuclear Dot-Associated Sp100 ProteinSpeckled 100 Kda |
| Database Links | Reactome: R-HSA-3108214Reactome: R-HSA-877300 |
| Cellular Localisation | NucleusPml BodyNuclear BodyCytoplasmDifferences In The Subnuclear Localization Of The Different Isoforms Seem To Exist And May Also Be Cell Cycle- And Interferon-DependentAccumulates In The Cytoplasm Upon Fas ActivationIsoform Sp100-C: NucleusForms A Reticulate Or Track-Like Nuclear Pattern With Denser Concentrations At The Nuclear Lamina And Surrounding The NucleoliA Pattern Reminiscent Of Heterochromatin-Rich Regions |
| Alternative Protein Names | Nuclear Autoantigen Sp-100 proteinNuclear Dot-Associated Sp100 Protein proteinSpeckled 100 Kda proteinSP100 protein |
Information sourced from Uniprot.org
