Human SMAD6 protein (Recombinant) (N-His) (STJP003281)

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STJP003281
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SMAD6-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SMAD6
Gene ID: 4091
Uniprot ID: SMAD6_HUMAN
Immunogen Region: Cys261-Pro495
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by BMP type 1 receptor kinase and by PRKX. Monoubiquitinated at Lys-173 by the E2/E3 hybrid ubiquitin-protein ligase UBE2O, leading to reduced binding affinity for the activated BMP type I receptor ACVR1/ALK2, thereby enhancing BMP7 and regulating adipocyte differentiation. Ubiquitinated by WWP1. Ubiquitinated by ARK2C, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling. Arginine methylation by PRMT1, which is recruited by BMPR2, initiates BMP-Induced signaling and induces dissociation from the BMPR1B receptor at the cell surface leading to derepress downstream Smad1/Smad5 signaling.
Function Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta. Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes. Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Protein Name Mothers Against Decapentaplegic Homolog 6
Mad Homolog 6
Mothers Against Dpp Homolog 6
Smad Family Member 6
Smad 6
Smad6
Hsmad6
Database Links Reactome: R-HSA-201451
Reactome: R-HSA-8941326
Cellular Localisation Nucleus
Alternative Protein Names Mothers Against Decapentaplegic Homolog 6 protein
Mad Homolog 6 protein
Mothers Against Dpp Homolog 6 protein
Smad Family Member 6 protein
Smad 6 protein
Smad6 protein
Hsmad6 protein
SMAD6 protein
MADH6 protein

Information sourced from Uniprot.org