| Post Translational Modifications | Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane. |
| Function | Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP. Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain. May transport glutamate. Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body. Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate. Xenobiotics include the mycotoxin ochratoxin (OTA). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier. |
| Protein Name | Solute Carrier Family 22 Member 6Organic Anion Transporter 1Hoat1Pah TransporterHpahtRenal Organic Anion Transporter 1Hroat1 |
| Database Links | Reactome: R-HSA-561048 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinBasal Cell MembraneLocalized To The Basolateral Membrane Of Renal Proximal Tubular CellsLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Protein Names | Solute Carrier Family 22 Member 6 proteinOrganic Anion Transporter 1 proteinHoat1 proteinPah Transporter proteinHpaht proteinRenal Organic Anion Transporter 1 proteinHroat1 proteinSLC22A6 proteinOAT1 proteinPAHT protein |
Information sourced from Uniprot.org
