| Post Translational Modifications | Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. |
| Function | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. |
| Protein Name | Sh3 And Px Domain-Containing Protein 2aAdapter Protein Tks5Five Sh3 Domain-Containing ProteinSh3 Multiple Domains Protein 1Tyrosine Kinase Substrate With Five Sh3 Domains |
| Database Links | Reactome: R-HSA-8941237Reactome: R-HSA-9013148 |
| Cellular Localisation | CytoplasmCell ProjectionPodosomeCytoplasmic In Normal Cells And Localizes To Podosomes In Src-Transformed Cells |
| Alternative Protein Names | Sh3 And Px Domain-Containing Protein 2a proteinAdapter Protein Tks5 proteinFive Sh3 Domain-Containing Protein proteinSh3 Multiple Domains Protein 1 proteinTyrosine Kinase Substrate With Five Sh3 Domains proteinSH3PXD2A proteinFISH proteinKIAA0418 proteinSH3MD1 proteinTKS5 protein |
Information sourced from Uniprot.org
