| Post Translational Modifications | Phosphorylated by DYRK1A. Ubiquitinated by AREL1. |
| Function | Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP. May also play a role in the regulation of cell fate in the intestine. Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis.via its interaction with XIAP. Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP. Plays an important role in male fertility and sperm motility. During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm. Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development. Required for dopaminergic metabolism in presynaptic autoreceptors.potentially via activity as a presynaptic scaffold protein. Isoform ARTS: Required for the induction of cell death mediated by TGF-beta and possibly by other apoptotic stimuli. Induces apoptosis through binding and inhibition of XIAP resulting in significant reduction in XIAP levels, leading to caspase activation and cell death. Mediates the interaction between BCL2 and XIAP, thereby positively regulating the ubiquitination and degradation of BCL2 and promoting apoptosis. |
| Protein Name | Septin-4Bradeion BetaBrain Protein H5Ce5b3 BetaCell Division Control-Related Protein 2Hcdcrel-2Peanut-Like Protein 2 |
| Database Links | Reactome: R-HSA-111457 O43236-6Reactome: R-HSA-111469 O43236-6 |
| Cellular Localisation | CytoplasmCell ProjectionCiliumFlagellumCytoplasmic VesicleSecretory VesicleAxonDendritePerikaryonSynapseIn PlateletsFound In Areas Surrounding Alpha-GranulesFound In The Sperm AnnulusA Fibrous Ring Structure Connecting The Midpiece And The Principal Piece Of The Sperm FlagellumExpressed And Colocalized With Slc6a3 And Snca In Axon TerminalsEspecially At The VaricositiesIsoform Arts: MitochondrionNucleusWhile Predominantly Localized In The Mitochondria Under Resting ConditionsTranslocates Into The Nucleus After Tgf-Beta Treatment And Apoptosis Induction |
| Alternative Protein Names | Septin-4 proteinBradeion Beta proteinBrain Protein H5 proteinCe5b3 Beta proteinCell Division Control-Related Protein 2 proteinHcdcrel-2 proteinPeanut-Like Protein 2 proteinSEPTIN4 proteinC17orf47 proteinPNUTL2 proteinSEP4 proteinSEPT4 proteinhucep-7 protein |
Information sourced from Uniprot.org
