| Function | Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions.the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins. Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2. |
| Protein Name | Protein FantomNephrocystin-8Rpgr-Interacting Protein 1-Like ProteinRpgrip1-Like Protein |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620912 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyCilium AxonemeMicrotubule Organizing CenterCentrosomeCell JunctionTight JunctionIn Cultured Renal CellsIt Localizes Diffusely In The Cytoplasm ButAs Cells Approach ConfluenceIt Accumulates To Basolateral Tight JunctionsLocalizes To The Ciliary Transition Zone |
| Alternative Protein Names | Protein Fantom proteinNephrocystin-8 proteinRpgr-Interacting Protein 1-Like Protein proteinRpgrip1-Like Protein proteinRPGRIP1L proteinFTM proteinKIAA1005 proteinNPHP8 protein |
Information sourced from Uniprot.org
