| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission.its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density. |
| Protein Name | Ring Finger Protein 112Brain Finger ProteinZinc Finger Protein 179 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinPeripheral Membrane ProteinCytoplasmNucleusNuclear BodyNucleoplasmEndosomeCytoplasmic VesicleSecretory VesicleSynaptic VesiclePostsynaptic DensityPerikaryonCell ProjectionNeuron ProjectionPredominantly In The NucleusBut Some Amounts Were Also Found In The CytoplasmOxidative Stress Stimulates Its Shuttling From The Cytoplasm Into The NucleusRecruited To Nuclear Bodies Via Its Interaction With Zbtb16Localizes To The Cell Soma And Neuritis And Only Slightly To The Nucleus In The Neurons Of Most Brain Areas |
| Alternative Protein Names | Ring Finger Protein 112 proteinBrain Finger Protein proteinZinc Finger Protein 179 proteinRNF112 proteinBFP proteinZNF179 protein |
Information sourced from Uniprot.org
