| Post Translational Modifications | Ubiquitinated in the presence of ITCH, or SMURF2, and UBE2D1, as well as WWP1. Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome. Acylation at both Gly-2 and Cys-4 is required for proper localization to the endosomes. |
| Function | Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. |
| Protein Name | Ring Finger Protein 11 |
| Cellular Localisation | Early EndosomeRecycling EndosomeCytoplasmNucleusPredominantly CytoplasmicWhen UnphosphorylatedAnd NuclearWhen Phosphorylated By Pkb/Akt1 |
| Alternative Protein Names | Ring Finger Protein 11 proteinRNF11 proteinCGI-123 protein |
Information sourced from Uniprot.org
