| Post Translational Modifications | Farnesylation is important for efficiently activating mTORC1-mediated signaling. Polyubiquitinated in response to amino acid, promoting its interaction with MTOR and mTORC1 activation. Deubiquitination by ATXN3 promotes recruitment of the TSC-TBC complex and RHEB inactivation by TSC2. Monoubiquitinated at Lys-8 by RNF152, promoting its association with the TSC-TBC complex. Deubiquitinated at Lys-8 by USP4, promoting mTORC1 activation. Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation. |
| Function | Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes. In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1. Has low intrinsic GTPase activity. |
| Protein Name | Gtp-Binding Protein RhebRas Homolog Enriched In Brain |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | Endomembrane SystemLipid-AnchorCytoplasmic SideLysosome MembraneGolgi Apparatus MembraneEndoplasmic Reticulum MembraneCytoplasmCytosolFarnesylation Is Required For Recruitment To Lysosomal MembranesWhere It Activates The Mtorc1 Complex |
| Alternative Protein Names | Gtp-Binding Protein Rheb proteinRas Homolog Enriched In Brain proteinRHEB proteinRHEB2 protein |
Information sourced from Uniprot.org
