| Function | Isoform A: RNA binding protein that mediates the regulation of pre-mRNA alternative splicing (AS). Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets. Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre-mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state. Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS-binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. Can also bind to CA dinucleotide repeats. Mediates repression of TPM1 exon 3 by binding to CAC tandem repeats in the flanking intronic regions, followed by higher-order oligomerization and heterotypic interactions with other splicing regulators including MBNL1 and RBFOX2, which prevents assembly of ATP-dependent splicing complexes. Isoform C: Acts as a regulator of pre-mRNA alternative splicing (AS). Binds mRNA. Regulates AS of ACTN1, FLNB, although with lower efficiency than isoform A / RBPMSA. Acts as coactivator of SMAD transcriptional activity in a TGFB1-dependent manner, possibly through increased phosphorylation of SMAD2 and SMAD3 at the C-terminal SSXS regions and promotion of the nuclear accumulation of SMAD proteins. |
| Protein Name | Rna-Binding Protein With Multiple SplicingRbp-MsRbpmsHeart And Rrm Expressed SequenceHermes |
| Cellular Localisation | NucleusCytoplasmStress GranuleP-BodyLocalized To Cytoplasmic Stress Granules After Oxidative StressTranslocates Into Cytoplasmic Stress Granules That Probably Corresponds To P-Bodies In Response To Oxidative Stress |
| Alternative Protein Names | Rna-Binding Protein With Multiple Splicing proteinRbp-Ms proteinRbpms proteinHeart And Rrm Expressed Sequence proteinHermes proteinRBPMS proteinHERMES protein |
Information sourced from Uniprot.org
