| Post Translational Modifications | Phosphorylated at Ser-165 by CDK1 during mitosis. Phosphorylated in vitro by ds-DNA kinase. Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10. |
| Function | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. |
| Protein Name | SecurinEsp1-Associated ProteinPituitary Tumor-Transforming Gene 1 ProteinTumor-Transforming Protein 1Hpttg |
| Database Links | Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-2467813 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Securin proteinEsp1-Associated Protein proteinPituitary Tumor-Transforming Gene 1 Protein proteinTumor-Transforming Protein 1 proteinHpttg proteinPTTG1 proteinEAP1 proteinPTTG proteinTUTR1 protein |
Information sourced from Uniprot.org
