| Post Translational Modifications | Subject to proteolytic cleavage at multiple sites. |
| Function | Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization. Has phosphatidylinositol phosphatase activity.the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate. Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis.upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase N2R-Ptp-N2Islet Cell Autoantigen-Related ProteinIarIcaarPhogrin Cleaved Into - Ia-2beta60 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cytoplasmic VesicleSecretory Vesicle MembraneSingle-Pass Type I Membrane ProteinSecretory VesicleSynaptic Vesicle MembranePredominantly Found On Dense-Core Secretory GranulesSorting To Secretory Granules In Part Is Dependent Of The N-Terminal Propeptide Domain Of The Precursor And Its Interaction With CpeTransiently Found At The Cell MembraneWhen Secretory Vesicles Fuse With The Cell Membrane To Release Their CargoIs Then Endocytosed And Recycled To Secretory Vesicles Involving Clathrin-Dependent Ap2-Mediated EndocytosisRecycled Via Stx6- But Not Tttgn1/Tgn38-Containing CompartmentsIa-2beta60: Cytoplasmic Vesicle |
| Alternative Protein Names | Receptor-Type Tyrosine-Protein Phosphatase N2 proteinR-Ptp-N2 proteinIslet Cell Autoantigen-Related Protein proteinIar proteinIcaar proteinPhogrin Cleaved Into - Ia-2beta60 proteinPTPRN2 proteinKIAA0387 protein |
Information sourced from Uniprot.org
