Human PTPN6 protein (Recombinant) (N-His) (STJP004491)

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STJP004491
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PTPN6-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PTPN6
Gene ID: 5777
Uniprot ID: PTN6_HUMAN
Immunogen Region: Phe244-Phe515
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation. Phosphorylation at Tyr-564 by LYN enhances phosphatase activity. Phosphorylation at Thr-394 by TAOK3 leads to polyubiquitination and subsequent proteasomal degradation. Ubiquitinated after phosphorylation by TAOK3. Ubiquitinated by a cooperation between ITCH and WWP2 via 'Lys-27'-mediated polyubiquitin chains resulting in the reduction of its association with LCK.
Function Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis. Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities. When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events. Modulates the signaling of several cytokine receptors including IL-4 receptor. Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling. Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Acts also as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A.
Protein Name Tyrosine-Protein Phosphatase Non-Receptor Type 6
Hematopoietic Cell Protein-Tyrosine Phosphatase
Protein-Tyrosine Phosphatase 1c
Ptp-1c
Protein-Tyrosine Phosphatase Shp-1
Sh-Ptp1
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-1433559
Reactome: R-HSA-201556
Reactome: R-HSA-210990
Reactome: R-HSA-388841
Reactome: R-HSA-389948
Reactome: R-HSA-391160
Reactome: R-HSA-432142
Reactome: R-HSA-512988
Reactome: R-HSA-5690714
Reactome: R-HSA-6798695
Reactome: R-HSA-877300
Reactome: R-HSA-877312
Reactome: R-HSA-9008059
Reactome: R-HSA-909733
Reactome: R-HSA-912526
Reactome: R-HSA-912694
Reactome: R-HSA-9705671
Reactome: R-HSA-9725371
Reactome: R-HSA-982772
Reactome: R-HSA-983695
Cellular Localisation Cytoplasm
Nucleus
In Neurons
Translocates Into The Nucleus After Treatment With Angiotensin Ii
Shuttles Between The Cytoplasm And Nucleus Via Its Association With Pdpk1
Alternative Protein Names Tyrosine-Protein Phosphatase Non-Receptor Type 6 protein
Hematopoietic Cell Protein-Tyrosine Phosphatase protein
Protein-Tyrosine Phosphatase 1c protein
Ptp-1c protein
Protein-Tyrosine Phosphatase Shp-1 protein
Sh-Ptp1 protein
PTPN6 protein
HCP protein
PTP1C protein

Information sourced from Uniprot.org