| Function | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification. Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites. |
| Protein Name | Serine/Threonine-Protein Kinase Plk4Polo-Like Kinase 4Plk-4Serine/Threonine-Protein Kinase 18Serine/Threonine-Protein Kinase Sak |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleNucleusNucleolusCleavage FurrowComponent Of The DeuterosomeA Structure That Promotes De Novo Centriole Amplification In Multiciliated Cells That Can Generate More Than 100 CentriolesAssociates With Centrioles Throughout The Cell CycleIt Is Not Present At Cleavage Furrows |
| Alternative Protein Names | Serine/Threonine-Protein Kinase Plk4 proteinPolo-Like Kinase 4 proteinPlk-4 proteinSerine/Threonine-Protein Kinase 18 proteinSerine/Threonine-Protein Kinase Sak proteinPLK4 proteinSAK proteinSTK18 protein |
Information sourced from Uniprot.org
