| Post Translational Modifications | C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage. |
| Function | Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. |
| Protein Name | Pleckstrin Homology Domain-Containing Family O Member 1Ph Domain-Containing Family O Member 1C-Jun-Binding ProteinJbpCasein Kinase 2-Interacting Protein 1Ck2-Interacting Protein 1Ckip-1Osteoclast Maturation-Associated Gene 120 Protein |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinNucleusCytoplasmPredominantly Localized To The Plasma Membrane Through The Binding To Phosphatidylinositol 3-PhosphateIn C2c12 CellsWith The Absence Of Growth FactorIt Is Found In The NucleusIt Rapidly Translocates To The Plasma Membrane After Insulin StimulationIn Response To TnfIt Translocates From The Plasma Membrane To The Cytoplasm And Then To The Nucleus Accompanied By Cleavage By Caspase-3HoweverThe Subcellular Location Is Highly Dependent Of The Cell TypeAnd This Explains Why It Is Found Exclusively At The Plasma MembraneIn Some Type Of Cells (Probable) |
| Alternative Protein Names | Pleckstrin Homology Domain-Containing Family O Member 1 proteinPh Domain-Containing Family O Member 1 proteinC-Jun-Binding Protein proteinJbp proteinCasein Kinase 2-Interacting Protein 1 proteinCk2-Interacting Protein 1 proteinCkip-1 proteinOsteoclast Maturation-Associated Gene 120 Protein proteinPLEKHO1 proteinCKIP1 proteinOC120 proteinHQ0024c protein |
Information sourced from Uniprot.org
