| Post Translational Modifications | Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its ability to induce centrosome amplification, chromosome instability and cell transformation. Ser-71 is dephosphorylated upon IL33-stimulation of dendritic cells. |
| Function | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner. Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN. May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 1Peptidyl-Prolyl Cis-Trans Isomerase Pin1Ppiase Pin1Rotamase Pin1 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-5668599Reactome: R-HSA-6804756Reactome: R-HSA-6811555Reactome: R-HSA-936440 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmColocalizes With Nek6 In The NucleusMainly Localized In The Nucleus But Phosphorylation At Ser-71 By Dapk1 Results In Inhibition Of Its Nuclear Localization |
| Alternative Protein Names | Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 1 proteinPeptidyl-Prolyl Cis-Trans Isomerase Pin1 proteinPpiase Pin1 proteinRotamase Pin1 proteinPIN1 protein |
Information sourced from Uniprot.org
