Human PDE4D protein (Recombinant) (N-His) (STJP007572)

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STJP007572
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PDE4D-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PDE4D
Gene ID: 5144
Uniprot ID: PDE4D_HUMAN
Immunogen Region: Glu391-Thr711
Immunogen: Homo sapiens (Human)
Post Translational Modifications Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation. Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59. Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation.
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Protein Name 3' -5'-Cyclic-Amp Phosphodiesterase 4d
Dpde3
Pde43
Camp-Specific Phosphodiesterase 4d
Database Links Reactome: R-HSA-180024
Reactome: R-HSA-418555
Cellular Localisation Apical Cell Membrane
Cytoplasm
Membrane
Cytoskeleton
Microtubule Organizing Center
Centrosome
Found In The Soluble Fraction
Associated With Membranes
And Associated With The Cytoskeleton And The Centrosome
Colocalized With Shank2 To The Apical Membrane Of Colonic Crypt Cells
Alternative Protein Names 3' -5'-Cyclic-Amp Phosphodiesterase 4d protein
Dpde3 protein
Pde43 protein
Camp-Specific Phosphodiesterase 4d protein
PDE4D protein
DPDE3 protein

Information sourced from Uniprot.org

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