Function | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. |
Protein Name | Beta-ParvinAffixin |
Database Links | Reactome: R-HSA-446353Reactome: R-HSA-446388 |
Cellular Localisation | Cell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell ProjectionLamellipodiumMyofibrilSarcomereZ LineConstituent Of Focal AdhesionsDetected At The Tips Of The Leading Edge Of CellsColocalizes With F-Actin At The Tips Of Lamellipodia |
Alternative Protein Names | Beta-Parvin proteinAffixin proteinPARVB proteinCGI-56 protein |
Information sourced from Uniprot.org