Human PAFAH2 protein (Recombinant) (N-His) (STJP005882)

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STJP005882
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PAFAH2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PAFAH2
Gene ID: 5051
Uniprot ID: PAFA2_HUMAN
Immunogen Region: Met1-Leu392
Immunogen: Homo sapiens (Human)
Function Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation. Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF. Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position.
Protein Name Platelet-Activating Factor Acetylhydrolase 2 - Cytoplasmic
Paf -Lysophospholipid Transacetylase
Paf -Sphingosine Transacetylase
Platelet-Activating Factor Acetyltransferase Pafah2
Serine-Dependent Phospholipase A2
Sd-Pla2
Hsd-Pla2
Database Links Reactome: R-HSA-418346
Cellular Localisation Cytoplasm
Membrane
Lipid-Anchor
Endoplasmic Reticulum Membrane
In Resting Cells
Localizes To Intracellular Membranes And Cytoplasm
Translocates From The Cytoplasm To Intracellular Membranes Upon Oxidative Stress
Alternative Protein Names Platelet-Activating Factor Acetylhydrolase 2 - Cytoplasmic protein
Paf -Lysophospholipid Transacetylase protein
Paf -Sphingosine Transacetylase protein
Platelet-Activating Factor Acetyltransferase Pafah2 protein
Serine-Dependent Phospholipase A2 protein
Sd-Pla2 protein
Hsd-Pla2 protein
PAFAH2 protein

Information sourced from Uniprot.org

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