Human OPG (Tumor Necrosis Factor Receptor Superfamily Member 11b) Antibody Pair (STJAP00054)

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STJAP00054-50
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Host: Mouse/Goat
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This OPG antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Monoclonal/Polyclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A or G.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: TNFRSF11B
Gene ID: 4982
Uniprot ID: TR11B_HUMAN
Immunogen: Capture immunogen: Recombinant Human OPG protein.
Detection Immunogen: Recombinant Human OPG protein.
Post Translational Modifications N-glycosylated. Contains sialic acid residues. The N-terminus is blocked.
Function Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 11b
Osteoclastogenesis Inhibitory Factor
Osteoprotegerin
Database Links Reactome: R-HSA-5669034
Cellular Localisation Secreted
Alternative Antibody Pair Names Tumor Necrosis Factor Receptor Superfamily Member 11b antibody pair
Osteoclastogenesis Inhibitory Factor antibody pair
Osteoprotegerin antibody pair
TNFRSF11B antibody pair
OCIF antibody pair
OPG antibody pair

Information sourced from Uniprot.org

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