| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human NUP153-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | NUP153 |
| Gene ID: | 9972 |
| Uniprot ID: | NU153_HUMAN |
| Immunogen Region: | Ser1238-Lys1468 |
| Immunogen: | Homo sapiens (Human) |
| Function | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus.in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). |
| Protein Name | Nuclear Pore Complex Protein Nup153153 Kda NucleoporinNucleoporin Nup153 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-6784531Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9705671 |
| Cellular Localisation | NucleusNucleus MembraneNuclear Pore ComplexTightly Associated With The Nuclear Membrane And LaminaLocalized To The Nucleoplasmic Side Of The Nuclear Pore Complex (Npc) Core StructureForming A Fibrous Structure Called The Nuclear BasketDissociates From The Npc Structure Early During Prophase Of MitosisIntegrated In The Newly Assembled Nuclear Envelope Of Postmitotic Cells Early In G1Colocalized With Nup98 And Tpr To The Nuclear Basket At The Nucleoplasmic Side Of The NpcDetected In Diffuse And Discrete Intranuclear FociRemained Localized To The Nuclear Membrane After Poliovirus (Pv) Infection |
| Alternative Protein Names | Nuclear Pore Complex Protein Nup153 protein153 Kda Nucleoporin proteinNucleoporin Nup153 proteinNUP153 protein |
Information sourced from Uniprot.org