Function | Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria. Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2). |
Protein Name | Protein Nipsnap Homolog 2Nipsnap2Glioblastoma-Amplified Sequence |
Database Links | Reactome: R-HSA-9013407Reactome: R-HSA-9013409 |
Cellular Localisation | Mitochondrion Matrix |
Alternative Protein Names | Protein Nipsnap Homolog 2 proteinNipsnap2 proteinGlioblastoma-Amplified Sequence proteinNIPSNAP2 proteinGBAS protein |
Information sourced from Uniprot.org