Human NIPSNAP2 protein (Recombinant) (N-His) (STJP010727)

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STJP010727
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NIPSNAP2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NIPSNAP2
Gene ID: 2631
Uniprot ID: NIPS2_HUMAN
Immunogen Region: Ala60-Gln286
Immunogen: Homo sapiens (Human)
Function Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria. Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2).
Protein Name Protein Nipsnap Homolog 2
Nipsnap2
Glioblastoma-Amplified Sequence
Database Links Reactome: R-HSA-9013407
Reactome: R-HSA-9013409
Cellular Localisation Mitochondrion Matrix
Alternative Protein Names Protein Nipsnap Homolog 2 protein
Nipsnap2 protein
Glioblastoma-Amplified Sequence protein
NIPSNAP2 protein
GBAS protein

Information sourced from Uniprot.org

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