Human NFATC1 protein (Recombinant) (N-His) (STJP010792)

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STJP010792
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NFATC1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NFATC1
Gene ID: 4772
Uniprot ID: NFAC1_HUMAN
Immunogen Region: Ser423-Ile700
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by NFATC-kinase and GSK3B.phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1.
Function Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.
Protein Name Nuclear Factor Of Activated T-Cells - Cytoplasmic 1
Nf-Atc1
Nfatc1
Nfat Transcription Complex Cytosolic Component
Nf-Atc
Nfatc
Database Links Reactome: R-HSA-2025928
Reactome: R-HSA-2871809
Reactome: R-HSA-4086398
Reactome: R-HSA-5607763
Cellular Localisation Cytoplasm
Nucleus
Cytoplasmic For The Phosphorylated Form And Nuclear After Activation That Is Controlled By Calcineurin-Mediated Dephosphorylation
Rapid Nuclear Exit Of Nfatc Is Thought To Be One Mechanism By Which Cells Distinguish Between Sustained And Transient Calcium Signals
Translocation To The Nucleus Is Increased In The Presence Of Calcium In Pre-Osteoblasts
The Subcellular Localization Of Nfatc Plays A Key Role In The Regulation Of Gene Transcription
Nuclear Translocation Of Nfatc1 Is Enhanced In The Presence Of Tnfsf11
Nuclear Translocation Is Decreased In The Presence Of Fbn1 Which Can Bind And Sequester Tnfsf11
Alternative Protein Names Nuclear Factor Of Activated T-Cells - Cytoplasmic 1 protein
Nf-Atc1 protein
Nfatc1 protein
Nfat Transcription Complex Cytosolic Component protein
Nf-Atc protein
Nfatc protein
NFATC1 protein
NFAT2 protein
NFATC protein

Information sourced from Uniprot.org