| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 28 pg/mL |
| Detection Limit: | 625-4000 pg/ml |
| Conjugation: | Biotin |
| Storage Instruction: | Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month. |
| Assay Time: | 3 hours |
| Detection: | Colorimetric |
| Gene Symbol: | MSTN |
| Gene ID: | 2660 |
| Uniprot ID: | GDF8_HUMAN |
| Sample Type: | serum, plasma and cell culture supernates |
| Tissue Specificity | |
| Post Translational Modifications | Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. |
| Function | Acts specifically as a negative regulator of skeletal muscle growth. |
| Protein Name | Growth/Differentiation Factor 8 Gdf-8 Myostatin |
| Database Links | Reactome: R-HSA-9617828 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Growth/Differentiation Factor 8 ELISA kit Gdf-8 ELISA kit Myostatin ELISA kit MSTN ELISA kit GDF8 ELISA kit |
| output |
Information sourced from Uniprot.org