| Post Translational Modifications | Phosphorylated by MAPK8, MAPK9 and MAPK10. Phosphorylation on Thr-103 is also necessary for the dissociation and activation of MAP3K12. Phosphorylated by isoform 1 and isoform 2 of VRK2. Hyperphosphorylated during mitosis following activation of stress-activated and MAP kinases. Ubiquitinated. Two preliminary events are required to prime for ubiquitination.phosphorylation and an increased in intracellular calcium concentration. Then, the calcium influx initiates ubiquitination and degradation by the ubiquitin-proteasome pathway. |
| Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. |
| Protein Name | C-Jun-Amino-Terminal Kinase-Interacting Protein 1Jip-1Jnk-Interacting Protein 1Islet-Brain 1Ib-1Jnk Map Kinase Scaffold Protein 1Mitogen-Activated Protein Kinase 8-Interacting Protein 1 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusEndoplasmic Reticulum MembraneMitochondrion MembraneAccumulates In Cell Surface ProjectionsUnder Certain Stress ConditionsTranslocates To The Perinuclear Region Of NeuronsIn Insulin-Secreting CellsDetected In Both The Cytoplasm And Nucleus |
| Alternative Protein Names | C-Jun-Amino-Terminal Kinase-Interacting Protein 1 proteinJip-1 proteinJnk-Interacting Protein 1 proteinIslet-Brain 1 proteinIb-1 proteinJnk Map Kinase Scaffold Protein 1 proteinMitogen-Activated Protein Kinase 8-Interacting Protein 1 proteinMAPK8IP1 proteinIB1 proteinJIP1 proteinPRKM8IP protein |
Information sourced from Uniprot.org
