| Post Translational Modifications | Phosphorylation by AMPK reduces its translocation towards the lipid droplets. |
| Function | Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs. Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs. Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. |
| Protein Name | Hormone-Sensitive LipaseHslMonoacylglycerol Lipase LipeRetinyl Ester HydrolaseReh |
| Database Links | Reactome: R-HSA-163560 |
| Cellular Localisation | Cell MembraneMembraneCaveolaCytoplasmCytosolLipid DropletFound In The High-Density CaveolaeTranslocates To The Cytoplasm From The Caveolae Upon Insulin StimulationPhosphorylation By Ampk Reduces Its Translocation Towards The Lipid Droplets |
| Alternative Protein Names | Hormone-Sensitive Lipase proteinHsl proteinMonoacylglycerol Lipase Lipe proteinRetinyl Ester Hydrolase proteinReh proteinLIPE protein |
Information sourced from Uniprot.org
