Human INPP4A (Inositol Polyphosphate-4-Phosphatase Type I 107kDa) Sandwich ELISA Kit Kit (STJE0010014)

Human INPP4A (Inositol Polyphosphate-4-Phosphatase Type I 107kDa) Sandwich ELISA Kit Kit (STJE0010014)

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STJE0010014
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.059ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This INPP4A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids..
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: INPP4A
Gene ID: 3631
Uniprot ID: INP4A_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
Post Translational Modifications
Function Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current. Isoform 4: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.
Protein Name Inositol Polyphosphate-4-Phosphatase Type I A
Inositol Polyphosphate 4-Phosphatase Type I
Type I Inositol 3 -4-Bisphosphate 4-Phosphatase
Database Links Reactome: R-HSA-1660499
Reactome: R-HSA-1660516
Reactome: R-HSA-1855183
Cellular Localisation Early Endosome Membrane
Recycling Endosome Membrane
Cell Membrane
Nucleus
Cytoplasm
Postsynaptic Density
Translocates To The Plasma Membrane Upon Egf Stimulation
Shuttles Between The Cytoplasm And The Nucleus
Depending On The Cell Cycle Stage
With Highest Amounts Detected In The Nucleus During The G0/G1phase
Alternative ELISA Names Inositol Polyphosphate-4-Phosphatase Type I A ELISA kit
Inositol Polyphosphate 4-Phosphatase Type I ELISA kit
Type I Inositol 3 -4-Bisphosphate 4-Phosphatase ELISA kit
INPP4A ELISA kit
output

Information sourced from Uniprot.org

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