| Post Translational Modifications | N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). |
| Function | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6. |
| Protein Name | Interleukin-36 BetaFil1 EtaInterleukin-1 EtaIl-1 EtaInterleukin-1 Family Member 8Il-1f8Interleukin-1 Homolog 2Il-1h2 |
| Database Links | Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Protein Names | Interleukin-36 Beta proteinFil1 Eta proteinInterleukin-1 Eta proteinIl-1 Eta proteinInterleukin-1 Family Member 8 proteinIl-1f8 proteinInterleukin-1 Homolog 2 proteinIl-1h2 proteinIL36B proteinIL1F8 proteinIL1H2 protein |
Information sourced from Uniprot.org
