Tissue Specificity | Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells. |
Post Translational Modifications | N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex. |
Function | Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3. |
Protein Name | Interleukin-18 Receptor 1Il-18r-1Il-18r1Cd218 Antigen-Like Family Member ACdw218aIl1 Receptor-Related ProteinIl-1rrpIl1r-RpInterleukin-18 Receptor AlphaIl-18r-AlphaIl-18ralphaCd Antigen Cd218a |
Database Links | Reactome: R-HSA-9008059Reactome: R-HSA-9012546 |
Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
Alternative ELISA Names | Interleukin-18 Receptor 1 ELISA kitIl-18r-1 ELISA kitIl-18r1 ELISA kitCd218 Antigen-Like Family Member A ELISA kitCdw218a ELISA kitIl1 Receptor-Related Protein ELISA kitIl-1rrp ELISA kitIl1r-Rp ELISA kitInterleukin-18 Receptor Alpha ELISA kitIl-18r-Alpha ELISA kitIl-18ralpha ELISA kitCd Antigen Cd218a ELISA kitIL18R1 ELISA kitIL1RRP ELISA kit |
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Information sourced from Uniprot.org