Function | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity.This activity may be required for transcriptional activation or repression of specific target promoters. These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. |
Protein Name | Helicase-Like Transcription FactorDna-Binding Protein/Plasminogen Activator Inhibitor 1 RegulatorHip116Ring Finger Protein 80Ring-Type E3 Ubiquitin Transferase HltfSwi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3Sucrose Nonfermenting Protein 2-Like 3 |
Database Links | Reactome: R-HSA-8866654 |
Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasmNuclear Localization Is Stimulated By Progesterone |
Alternative Protein Names | Helicase-Like Transcription Factor proteinDna-Binding Protein/Plasminogen Activator Inhibitor 1 Regulator proteinHip116 proteinRing Finger Protein 80 proteinRing-Type E3 Ubiquitin Transferase Hltf proteinSwi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3 proteinSucrose Nonfermenting Protein 2-Like 3 proteinHLTF proteinHIP116A proteinRNF80 proteinSMARCA3 proteinSNF2L3 proteinZBU1 protein |
Information sourced from Uniprot.org