Human HLTF protein (Recombinant) (N-His) (STJP006666)

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STJP006666
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HLTF-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HLTF
Gene ID: 6596
Uniprot ID: HLTF_HUMAN
Immunogen Region: Ala837-Lys996
Immunogen: Homo sapiens (Human)
Function Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity.This activity may be required for transcriptional activation or repression of specific target promoters. These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Protein Name Helicase-Like Transcription Factor
Dna-Binding Protein/Plasminogen Activator Inhibitor 1 Regulator
Hip116
Ring Finger Protein 80
Ring-Type E3 Ubiquitin Transferase Hltf
Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3
Sucrose Nonfermenting Protein 2-Like 3
Database Links Reactome: R-HSA-8866654
Cellular Localisation Cytoplasm
Nucleus
Nucleolus
Nucleoplasm
Nuclear Localization Is Stimulated By Progesterone
Alternative Protein Names Helicase-Like Transcription Factor protein
Dna-Binding Protein/Plasminogen Activator Inhibitor 1 Regulator protein
Hip116 protein
Ring Finger Protein 80 protein
Ring-Type E3 Ubiquitin Transferase Hltf protein
Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3 protein
Sucrose Nonfermenting Protein 2-Like 3 protein
HLTF protein
HIP116A protein
RNF80 protein
SMARCA3 protein
SNF2L3 protein
ZBU1 protein

Information sourced from Uniprot.org