Human HER3 (ERBB3) protein (Recombinant) {Biotin} (STJP000716)
SPECIFICATIONS
HostCHO Cells
ConjugationBiotin
ImmunogenDNA sequence encoding extracellular domain of Human HER3 (ERBB3) to a C-terminal polyHis tag was expressed in CHO cells. NA
General Information
| Short Description | Recombinant-Human HER3 (ERBB3)-protein was developed from cho cells. For use in research applications. |
| Applications | ELISA/WB |
| Host | CHO Cells |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Dilution Range | Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Formulation | Lyophilised from 0.2 Mu m filtered PBS pH 7.4. |
| Storage Instruction | Can be stored in working aliquots at 2ยฐC-8ยฐC C for one month, or at-20ยฐC C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ยตg (1EU/ยตg). NA |
Target Information
| Gene Symbol | ERBB3 |
| Gene ID | 2065 |
| Uniprot ID | ERBB3_HUMAN |
| Immunogen | DNA sequence encoding extracellular domain of Human HER3 (ERBB3) to a C-terminal polyHis tag was expressed in CHO cells. NA |
| Immunogen Region | ECD |
Additional Info
| Tissue Specificity | Epithelial tissues and brain. |
| Post Translational Modifications | Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. |
| Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it.ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. |
| Protein Name | Receptor Tyrosine-Protein Kinase Erbb-3Proto-Oncogene-Like Protein C-Erbb-3Tyrosine Kinase-Type Cell Surface Receptor Her3 |
| Database Links | Reactome: R-HSA-1227986 P21860-1Reactome: R-HSA-1236394 P21860-1Reactome: R-HSA-1250196 P21860-1Reactome: R-HSA-1257604 P21860-1Reactome: R-HSA-1306955 P21860-1Reactome: R-HSA-1358803 P21860-1Reactome: R-HSA-1963642 P21860-1Reactome: R-HSA-2219530 P21860-1Reactome: R-HSA-5673001 P21860-1Reactome: R-HSA-6785631 P21860-1Reactome: R-HSA-6811558 P21860-1Reactome: R-HSA-8847993 P21860-1Reactome: R-HSA-8863795 P21860-1Reactome: R-HSA-9664565 P21860-1Reactome: R-HSA-9665686 P21860-1 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Receptor Tyrosine-Protein Kinase Erbb-3 proteinProto-Oncogene-Like Protein C-Erbb-3 proteinTyrosine Kinase-Type Cell Surface Receptor Her3 proteinERBB3 proteinHER3 protein |
Information sourced from Uniprot.org