Human HER3 (ERBB3) protein (Recombinant) {Biotin} (STJP000716)

SKU:
STJP000716

Current Stock:
Host: CHO cells
Applications: ELISA, WB
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Recombinant-Human HER3 (ERBB3)-protein was developed from cho cells. For use in research applications.
Conjugation: Biotin
Formulation: Recombinant Human HER2 was lyophilized from a 0.2 Mu m filtered PBS pH 7.4.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: The lyophilized protein is stable for at least 2 years from date of receipt at-20°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8°C for one month, or at-20°C for six months, with a carrier protein without detectable los
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: ERBB3
Gene ID: 2065
Uniprot ID: ERBB3_HUMAN
Immunogen Region: ECD
Tissue Specificity Epithelial tissues and brain.
Post Translational Modifications Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.
Function Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it.ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
Protein Name Receptor Tyrosine-Protein Kinase Erbb-3
Proto-Oncogene-Like Protein C-Erbb-3
Tyrosine Kinase-Type Cell Surface Receptor Her3
Database Links Reactome: R-HSA-1227986 P21860-1
Reactome: R-HSA-1236394 P21860-1
Reactome: R-HSA-1250196 P21860-1
Reactome: R-HSA-1257604 P21860-1
Reactome: R-HSA-1306955 P21860-1
Reactome: R-HSA-1358803 P21860-1
Reactome: R-HSA-1963642 P21860-1
Reactome: R-HSA-2219530 P21860-1
Reactome: R-HSA-5673001 P21860-1
Reactome: R-HSA-6785631 P21860-1
Reactome: R-HSA-6811558 P21860-1
Reactome: R-HSA-8847993 P21860-1
Reactome: R-HSA-8863795 P21860-1
Reactome: R-HSA-9664565 P21860-1
Reactome: R-HSA-9665686 P21860-1
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Antibody Names Anti-Receptor Tyrosine-Protein Kinase Erbb-3 antibody
Anti-Proto-Oncogene-Like Protein C-Erbb-3 antibody
Anti-Tyrosine Kinase-Type Cell Surface Receptor Her3 antibody
Anti-ERBB3 antibody
Anti-HER3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance