| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.057ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This H2AFV Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | H2AZ2 |
| Gene ID: | 94239 |
| Uniprot ID: | H2AV_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression. Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis. |
| Function | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. |
| Protein Name | Histone H2a.vH2a.f/ZH2a.z Variant Histone 2 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-1221632Reactome: R-HSA-171306Reactome: R-HSA-1912408Reactome: R-HSA-201722Reactome: R-HSA-212300Reactome: R-HSA-2299718Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-2559586Reactome: R-HSA-3214858Reactome: R-HSA-427359Reactome: R-HSA-427389Reactome: R-HSA-427413Reactome: R-HSA-5250924Reactome: R-HSA-5334118Reactome: R-HSA-5578749Reactome: R-HSA-5617472Reactome: R-HSA-5625886Reactome: R-HSA-606279Reactome: R-HSA-68616Reactome: R-HSA-73728Reactome: R-HSA-73772Reactome: R-HSA-8936459Reactome: R-HSA-8939236Reactome: R-HSA-9018519Reactome: R-HSA-912446Reactome: R-HSA-9616222Reactome: R-HSA-9670095Reactome: R-HSA-9710421 |
| Cellular Localisation | NucleusChromosome |
| Alternative ELISA Names | Histone H2a.v ELISA kitH2a.f/Z ELISA kitH2a.z Variant Histone 2 ELISA kitH2AZ2 ELISA kitH2AFV ELISA kitH2AV ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
