Human GRM1 protein (Recombinant) (N-His) (STJP005309)

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STJP005309
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GRM1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GRM1
Gene ID: 2911
Uniprot ID: GRM1_HUMAN
Immunogen Region: Ser165-Glu592
Immunogen: Homo sapiens (Human)
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. May function in the light response in the retina. Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively.
Protein Name Metabotropic Glutamate Receptor 1
Mglur1
Database Links Reactome: R-HSA-416476
Reactome: R-HSA-420499
Reactome: R-HSA-6794361
Reactome: R-HSA-9717207
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Alternative Protein Names Metabotropic Glutamate Receptor 1 protein
Mglur1 protein
GRM1 protein
GPRC1A protein
MGLUR1 protein

Information sourced from Uniprot.org