Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. May function in the light response in the retina. Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively. |
Protein Name | Metabotropic Glutamate Receptor 1Mglur1 |
Database Links | Reactome: R-HSA-416476Reactome: R-HSA-420499Reactome: R-HSA-6794361Reactome: R-HSA-9717207 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell Membrane |
Alternative Protein Names | Metabotropic Glutamate Receptor 1 proteinMglur1 proteinGRM1 proteinGPRC1A proteinMGLUR1 protein |
Information sourced from Uniprot.org