Human GNAO1 protein (Recombinant) (N-His) (STJP007781)

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STJP007781
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GNAO1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GNAO1
Gene ID: 2775
Uniprot ID: GNAO_HUMAN
Immunogen Region: Met1-Tyr354
Immunogen: Homo sapiens (Human)
Function Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels.
Protein Name Guanine Nucleotide-Binding Protein G(O Subunit Alpha
Database Links Reactome: R-HSA-4086398
Cellular Localisation Cell Membrane
Membrane
Lipid-Anchor
Alternative Protein Names Guanine Nucleotide-Binding Protein G(O Subunit Alpha protein
GNAO1 protein

Information sourced from Uniprot.org

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