| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human GARP&Latent TGF beta 1 Complex-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications. |
| Conjugation: | Biotin |
| Formulation: | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Dilution Range: | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Storage Instruction: | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
| Gene Symbol: | LRRC32 |
| Gene ID: | 2615 |
| Uniprot ID: | LRC32_HUMAN |
| Immunogen Region: | His20-Leu628 (GARP) & Leu30-Ser390 (Latent TGF beta 1) |
| Immunogen: | DNA sequence encoding Human GARP&Latent TGF beta 1 Complex including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3). |
| Protein Name | Transforming Growth Factor Beta Activator Lrrc32GarpinGlycoprotein A Repetitions PredominantGarpLeucine-Rich Repeat-Containing Protein 32 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell Surface |
| Alternative Protein Names | Transforming Growth Factor Beta Activator Lrrc32 proteinGarpin proteinGlycoprotein A Repetitions Predominant proteinGarp proteinLeucine-Rich Repeat-Containing Protein 32 proteinLRRC32 proteinD11S833E protein |
Information sourced from Uniprot.org
