| Post Translational Modifications | Phosphorylation by CK2 results in loss of HSP90 binding activity. |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4Ppiase Fkbp451 Kda Fk506-Binding ProteinFkbp5152 Kda Fk506-Binding Protein52 Kda FkbpFkbp-5259 Kda ImmunophilinP59Fk506-Binding Protein 4Fkbp-4Fkbp59Hsp-Binding ImmunophilinHbiImmunophilin Fkbp52Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-3371568Reactome: R-HSA-8939211Reactome: R-HSA-9018519Reactome: R-HSA-9679191 |
| Cellular Localisation | CytoplasmCytosolMitochondrionNucleusCytoskeletonCell ProjectionAxonShuttles From Mitochondria To NucleusCo-Localizes In Mitochondria With The Glucocorticoid ReceptorColocalized With Mapt/Tau In The Distal Part Of The Primary Cortical Neurons |
| Alternative Protein Names | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 proteinPpiase Fkbp4 protein51 Kda Fk506-Binding Protein proteinFkbp51 protein52 Kda Fk506-Binding Protein protein52 Kda Fkbp proteinFkbp-52 protein59 Kda Immunophilin proteinP59 proteinFk506-Binding Protein 4 proteinFkbp-4 proteinFkbp59 proteinHsp-Binding Immunophilin proteinHbi proteinImmunophilin Fkbp52 proteinRotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed proteinFKBP4 proteinFKBP52 protein |
Information sourced from Uniprot.org
