| Tissue Specificity | Overexpressed in several carcinomas. |
| Post Translational Modifications | Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1. Ubiquitinated. |
| Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. |
| Protein Name | Ephrin Type-A Receptor 1Hepha1Eph Tyrosine KinaseEph Tyrosine Kinase 1Erythropoietin-Producing Hepatoma ReceptorTyrosine-Protein Kinase Receptor Eph |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-2892247Reactome: R-HSA-3928663Reactome: R-HSA-3928665 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative ELISA Names | Ephrin Type-A Receptor 1 ELISA kitHepha1 ELISA kitEph Tyrosine Kinase ELISA kitEph Tyrosine Kinase 1 ELISA kitErythropoietin-Producing Hepatoma Receptor ELISA kitTyrosine-Protein Kinase Receptor Eph ELISA kitEPHA1 ELISA kitEPH ELISA kitEPHT ELISA kitEPHT1 ELISA kit |
| output | |
Information sourced from Uniprot.org
