| Tissue Specificity | Expressed in keratinocytes (at protein level). |
| Post Translational Modifications | Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation. |
| Function | Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. |
| Protein Name | Dual Specificity Protein Phosphatase 6Dual Specificity Protein Phosphatase Pyst1Mitogen-Activated Protein Kinase Phosphatase 3Map Kinase Phosphatase 3Mkp-3 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-202670Reactome: R-HSA-5675221Reactome: R-HSA-9652817 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Dual Specificity Protein Phosphatase 6 ELISA kitDual Specificity Protein Phosphatase Pyst1 ELISA kitMitogen-Activated Protein Kinase Phosphatase 3 ELISA kitMap Kinase Phosphatase 3 ELISA kitMkp-3 ELISA kitDUSP6 ELISA kitMKP3 ELISA kitPYST1 ELISA kit |
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Information sourced from Uniprot.org
