| Function | Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses. G4 structures correspond to helical structures containing guanine tetrads. Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription. Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression. Plays a role in post-transcriptional regulation. Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage. Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment. Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size. Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability. Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression. Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively. Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation. Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification. |
| Protein Name | Atp-Dependent Dna/Rna Helicase Dhx36Dead/H Box Polypeptide 36Deah-Box Protein 36G4-Resolvase-1G4r1Mle-Like Protein 1Rna Helicase Associated With Au-Rich Element Protein |
| Database Links | Reactome: R-HSA-3134963 |
| Cellular Localisation | NucleusCytoplasmCytosolStress GranuleNucleus SpeckleChromosomeTelomereMitochondrionPerikaryonCell ProjectionDendriteAxonPredominantly Localized In The NucleusColocalizes With Srsf2 In Nuclear SpecklesColocalizes With Ddx5 In Nucleolar Caps Upon Transcription InhibitionAccumulates And Colocalized With Tia1 In Cytoplasmic Stress Granules (Sgs) In An Arsenite-Heat Shock- And Rna-Binding-Dependent MannerShuttles Into And Out Of Sgs In An Atpase-Dependent MannerColocalizes In The Cytosol With The Multi-Helicase-Ticam1 Complex That Translocates To The Mitochondria Upon Poly(I:c) Rna Ligand StimulationIsoform 1: NucleusPreferentially Localized In The NucleusExcluded From NucleoliIsoform 2: NucleusPreferentially Localized In The Cytoplasm |
| Alternative Protein Names | Atp-Dependent Dna/Rna Helicase Dhx36 proteinDead/H Box Polypeptide 36 proteinDeah-Box Protein 36 proteinG4-Resolvase-1 proteinG4r1 proteinMle-Like Protein 1 proteinRna Helicase Associated With Au-Rich Element Protein proteinDHX36 proteinDDX36 proteinKIAA1488 proteinMLEL1 proteinRHAU protein |
Information sourced from Uniprot.org
